【24drs.com】November 5, 2009 (波士頓) — 根據美國肝病研究協會(American Association for the Study of Liver Diseases，AASLD)第60屆年會、2009肝臟會議中，一篇最新報告的結果摘要，以長效型干擾素-alfa2b和ribavirin治療時，每天補充維他命D可增加病毒性反應率。
第一研究者、以色列Hillel Yaffe醫學中心肝臟科的Saif M. Abu-Mouch醫師等人在摘要中指出，維他命D是強力的免疫調節劑，對於以干擾素為基礎之慢性C型肝炎治療的病毒性反應影響則未知。
維他命D組的身體質量指數(27 vs 24 kg/m2；P< .01)、病毒載量(68% vs 58%；P< .01)、纖維化(Metavir評分> F2，55% vs 18%；P< .001)，都比未接受維他命D組高。兩研究組的人口統計學資料、疾病特徵、種族、開始時的生化參數、對治療的遵從性都相似。
November 5, 2009 (Boston, Massachusetts) — Supplementing pegylated interferon-alfa2b and ribavirin with a daily dose of vitamin?D might increase virologic response rates, according to results of a late-breaking abstract reported here at The Liver Meeting 2009, the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD).
"Vitamin?D is a potent immunomodulator whose impact on virologic response rates of interferon-based treatment of chronic HCV [hepatitis?C] is unknown," lead investigator Saif M. Abu-Mouch, MD, from the Department of Hepatology, Hillel Yaffe Medical Center, in Hadera, Israel, and colleagues note in their abstract.
"This preliminary study confirms the benefit of adding vitamin?D to conventional antiviral therapy in patients with chronic HCV," Dr. Abu-Mouch told meeting attendees.
In the study, 58 patients with confirmed chronic HCV (genotype?1) were randomly assigned to peginterferon-alfa2b (1.5?μg/kg once weekly) plus ribavirin (1000 to 2000?mg/day). Thirty-one patients also received vitamin?D (1000 to 4000?IU/day; serum level >32?ng/mL).
The vitamin?D group had a higher mean body mass index (27 vs 24?kg/m2; P?< .01), viral load (68% vs 58%; P?< .01), and fibrosis (Metavir scores > F2, 55% vs 18%; P?< .001) than the group that did not receive vitamin?D. Demographics, disease characteristics, ethnicity, baseline biochemical parameters, and adherence to treatment were similar in the 2 study groups.
A rapid virologic response was seen at week 4 in 44% of the vitamin?D group and in 18% of the control group. At week 12, Dr. Abu-Mouch told Medscape Gastroenterology, 96% of the vitamin?D group (26 of 27 patients) were HCV RNA-negative, as assessed by reverse-transcriptase polymerase chain reaction, as was 48% of the control group (15 of 31 patients), which was a significant difference (P?< .001), he said.
The combination of peginterferon and ribavirin, the standard of care for chronic HCV, achieves a sustained virologic response in 40% to 50% of naive patients with genotype?1, the investigators explain in a meeting abstract. Vitamin?D in combination with peginterferon-ribavirin "may have synergistic effects," Dr. Abu-Mouch said.
Meeting attendee Laurent Tsakiris, MD, from the Centre Hospitalier Universitaire de Melun in France, who was not involved in the study, told Medscape Gastroenterology that "the study is surprising and promising because vitamin?D is something very easy to use and there is no toxicity."
"It's also interesting," he said, "that the group treated with vitamin?D had more severe disease than the control group. I think this can be considered a strong result from a small study.
The study did not receive commercial support. Dr. Abu-Mouch and Dr. Tsakiris have disclosed no relevant financial relationships.
The Liver Meeting 2009: 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD): Abstract LB20. Presented November 2, 2009.
