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作者：Robert Lowes  
出處：WebMD醫學新聞

　　October 12, 2009 — 根據國家過敏與感染症研究中心(NIAID)贊助的一個試驗的初步資料，一手注射H1N1流感疫苗，另一手施打季節性流感疫苗，兩者的免疫反應效果都不會減低。
　　
　　NIAID主任Anthony Fauci醫師週五在記者會時表示，這對我們展開疫苗接種計畫來說是重要的，民眾前往醫師診間時可能提出同時接種疫苗的要求。Fauci醫師表示，同時施打也不會造成副作用增加。
　　
　　之前，美國疾病控制預防中心建議醫師，可以同時給予病患無病毒活性季節性流感和H1N1流感疫苗，或者一前一後依序給予。NIAID的公告指出，在許多選項中，該試驗的初步結果確認這項同時給予疫苗的建議。
　　
　　該試驗並未評估一種含有減毒病毒之鼻噴型疫苗的免疫反應。MedImmune公司製造了此類型的季節性流感和H1N1流感疫苗。NIAID的聲明指出，有關同時給予一種無病毒活性的疫苗和另一種鼻噴型流感疫苗的綜合指引建議，可參考CDC網站上的「H1N1臨床醫師問答」。
　　
　　【兩劑的H1N1疫苗不會顯著增加免疫力】
　　Fauci醫師表示，NIAID贊助之試驗的後續發現認為，連續兩劑H1N1疫苗的免疫力效果並未優於一劑的效果。
　　
　　該試驗初步指出，一劑15-μg劑量的無添加佐劑、無病毒活性物可誘發健康成人和老年人的有效免疫反應。試驗中的研究對象在第一劑後21天也接受第二劑。Fauci醫師表示，不過，第二劑之後8到10天，免疫反應並未優於第一劑後21天的效果。
　　
　　他表示，這確認了單一劑15-μg劑量的無添加佐劑、無病毒活性物，已足以誘導出預期獲得的反應。
　　
　　可在NIAID網站獲得本篇新聞的全文。
　　  

No Loss of Efficacy When H1N1, Seasonal Flu Vaccines Given Simultaneously

By Robert Lowes
Medscape Medical News

October 12, 2009 — Injecting patients with the H1N1 flu vaccine in one arm and the seasonal flu vaccine in the other does not impair the effectiveness of either in producing an immune response, according to early data from a trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).

"That will be important as we roll out the vaccination program and individuals...go to their [physician's] offices and would like to get those vaccinations at the same time," said NIAID Director Anthony Fauci, MD, at a Friday press conference. Administering the vaccines together also is not leading to greater adverse effects, said Dr. Fauci.

Previously, the US Centers for Disease Control and Prevention had advised clinicians that they could administer inactivated versions of both the seasonal flu vaccine and the H1N1 vaccine during the same patient visit, or any time before or after each other. Preliminary results from the trial confirm the recommendation for vaccine coadministration as one of several options, NIAID stated in a bulletin.

The trial is not assessing immune response to nasal-spray vaccines that contain a live, but weakened virus. A company called MedImmune makes such vaccines for both the H1NI and seasonal flu viruses. For comprehensive guidance on administering combinations of the inactivated vaccines and their nasal-spray counterparts for both strains of influenza, visit the "H1N1 Clinicians Questions and Answers" page of the CDC Web site, the NIAID release states.

2 Doses of H1N1 Vaccine Do Not Substantially Increase Immunity

Ongoing findings from the NIAID-sponsored trial also suggest that 2 sequential doses of the H1N1 virus do not confer greater immunity than 1 dose, Dr. Fauci said.

The trial initially indicated that within 8 to 10 days, a single, 15-μg dose of unadjuvanted, inactivated viral material triggered an effective immune response in healthy adults as well as the elderly. Patients in the trial also received a second dose 21 days after the first one. However, 8 to 10 days after the second dose, the immune response was not substantially greater than that seen at 21 days after the first dose, said Dr. Fauci.

"That just confirms the concept that a single dose of 15 μg of unadjuvanted material is sufficient to induce a robust response that you would be predict would be protective," he said.

The full text of the news release is available on the NIAID Web site.